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High blood underactive pressure, high cholesterol levels, or high blood sugar levels are all warning signs of some obesity-associated diseases.

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If you have close relatives who have had heart disease or diabetes, you are more likely to develop these problems if you are obese.

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If your weight is concentrated around your waist, you may have a higher risk of heart disease, diabetes, or cancer than people of the same weight who have a pear shape.

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In addition, recent research has shown that a 5- to 7-percent weight loss can prevent type 2 diabetes in people at high risk for the disease.

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Several weight-loss medications are available to treat obesity. In general, these medications are modestly effective, leading to an average weight loss of 5 to 22 pounds above that expected with non-drug obesity treatments. People respond differently to weight-loss medications, and some people experience more weight loss than underactive others. Some obese patients using medication lose more than 10 percent of their starting body weight--an amount of weight loss that may reduce risk factors for obesity-related diseases, such as high blood pressure or diabetes. Maximum weight loss usually occurs within 6 months of starting medication treatment. Weight then tends underactive to level off or increase during the remainder of treatment. Studies suggest that if a patient does not lose at least 4 pounds over 4 weeks on a particular medication, then that medication is unlikely to help the patient achieve significant weight loss. Few studies have looked at how safe underactive or effective these medications are when taken for more than 1 year. Both orlistat and sibutramine have been studied for as long as 2 years in some patients.

Some antidepressant medications have been studied as appetite-suppressant medications. While these medications are FDA approved for the treatment of depression, their underactive use in weight loss is an off-label use. Studies of these medications generally have found that patients lost modest amounts of weight for up to 6 months. However, most studies have found that patients who lost weight while taking antidepressant medications tended to regain weight while they were still on underactive the drug treatment. Amphetamines and closely related compounds are not recommended for use in the treatment of obesity due to their potential for abuse and dependence.